Objective To explore the application of thermogravimetric analysis(TGA)and Differential scanning calorimetry(DSC)in drug analysis to lay the foundation for pharmaceutical quality control.Methods a short overview of the applicative research on the water content,thermal stability,melting-point,purity,polymorphism and others in recent years,had been reported.The future development prospect was also discussed.Results and Conclusion TGA and DSC played an important role in the analysis of moisture,melting point,purity,crystallinity and stability of drugs to meet the higher analytical demands of pharmaceutical inspection and testing.It was looking forward to providing methods and ideas for the further research on drug quality and safety.