首页|上皮间质转化与肝纤维化之间的联系研究进展

上皮间质转化与肝纤维化之间的联系研究进展

Research progress in correlations between epithelial-mesenchymal transition and hepatic fibrosis

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肝纤维化是一个病理生理过程,指由各种致病因子所致肝内结缔组织异常增生.任何肝脏损伤在肝脏修复愈合的过程中都有肝纤维化的过程,如果损伤因素长期不能去除,纤维化的过程长期持续就会发展成肝硬化甚至是肝癌,因此逆转肝纤维化具有重要意义.近年来上皮间质转化的研究越来越多,研究发现肝纤维化中同样存在上皮间质转化,因此逆转上皮间质转化是逆转肝纤维化的机制之一,本文综述了在肝纤维化中发生上皮间质转化的细胞类型、上皮间质转化相关信号通路在肝纤维化中的作用机制以及通过上皮间质转化影响肝纤维化的非编码RNA,以期为肝纤维化的研究治疗提供理论依据.
Hepatic fibrosis is a pathophysiological process,which refers to abnormal hyperplasia of hepatic connective tissue caused by various pathogenic factors.Any liver injury undergoes liver fibrosis in the process of liver repair and healing.As long as injury persists,fibrosis will evolve into cirrhosis or even liver cancer.Therefore,it is of great significance to reverse liver fibrosis.In recent years,increasing research has been conducted on epithelial mesenchymal transition that has been found to occur in liver fibrosis,which is why reversing epithelial mesenchymal transition is one of the mechanisms for reversing liver fibrosis.This paper reviews the cell types of epithelial mesenchymal transition in hepatic fibrosis,the mechanism of epithelial mesenchymal transition-related signaling pathways in hepatic fibrosis,and the non-coding RNAs that affects hepatic fibrosis through epithelial mesenchymal transition in order to provide data the research and treatment of hepatic fibrosis.

epithelial-mesenchymal transitionhepatic fibrosisliver cancersignal transduction pathwaynon-coding RNAreverse

李明奇、赵晓璐、高晓阳、马月宏

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内蒙古医科大学基础医学院,内蒙古 呼和浩特 010110

上皮间质转化 肝纤维化 肝癌 信号转导通路 非编码RNA 逆转

国家自然科学基金国家自然科学基金内蒙古自治区自然科学基金内蒙古自治区自然科学基金内蒙古自治区草原英才培养计划内蒙古医科大学致远人才项目内蒙古自治区人才开发基金内蒙古医科大学重点项目内蒙古医科大学蒙药抗肝纤维化作用研究科技创新团队项目

81960759815607062019MS080102014MS0841ZY020101222056YKD2022ZD019YKD2022TD039

2024

10.19803/j.1672-8629.20230536

中国药物警戒
国家药品监督管理局药品评价中心（国家药品不良反应监测中心）

中国药物警戒

CSTPCD
影响因子：1.105
ISSN：1672-8629
年,卷(期)：2024.21(4)
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