Objective To analyze the risks of liver injury posed by Shiduqing preparations and provide reference for proper clinical use.Methods Literature about adverse reactions related to Shiduqing preparations in China's adverse drug reaction monitoring database(collected between 2004 and 2023)and domestic database(from inception to December 31,2023)was sorted out and analyzed.Results The National Adverse Drug Reaction Monitoring System Database documented 24 cases of adverse reactions related to liver and gallbladder damage and involving Shiduqing preparations.No adverse reactions related to hepatobiliary damage were found in clinical studies.The adverse reactions mentioned in individual reports were drug induced liver disease and liver injury.Conclusion Clinicians should be alert to the risk of liver injury when Shiduqing preparations are used in clinic.The awareness of safe and proper medications should be raised,and medications monitored.At the same time,drug marketing authorization holders should strengthen pharmacovigilance and provide guidance to ensure safe medication.
维普
万方数据
