Peroxisome proliferator-activated receptors(PPARs)are members of the nuclear factor family activated by endogenous or exogenous ligands,which regulate adipogenesis and metabolism,inflammation and other transcriptional modulators of crosstalk such as factor signaling in fibrosis progression.They have become a promising therapeutic target in recent years.Hepatic fibrosis(HF)is a complex pathological change mainly caused by collagen deposition and extracellular matrix(ECM)increases due to various etiologies,in which activated hepatic stellate cells(HSCs)play a pivotal role.Studies on PPARs have found that the expressions of its isoform PPARγ in adipose tissue,macrophages and HSCs are involved in inflammation,which leads to the formation of liver fibrosis.The upregulation of PAARγ maintains HSCs in reversing liver fibrosis.The quiescent phenotype and the promotion of apoptosis of activated HSCs also make a difference,suggesting that ligand-activated drugs targeting PAARγ may play an important role in anti-fibrotic therapy.
关键词
氧化物酶体增殖激活受体/PPARγ/肝纤维化/肝星状细胞/配体药物/药物研发
Key words
PPARs/PPARγ/liver fibrosis/hepatic stellate cells/ligand drug/drug development
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