Objective To find out about the establishment and applications of animal models for drug-induced cardiotoxicity,and to provide data for the prevention and treatment of drug-induced cardiotoxicity.Methods Literature research was conducted using"cardiotoxicity"as the key term.Related literature on applications of drug-induced cardiotoxicity models published since 2015 was selected from the CNKI and Web of Science Core Collection databases.Literature about experimental research on applications of animal models for drug-induced cardiotoxicity was screened based on the inclusion criteria.Analysis software Citespace 6.3 R1(64-bit)Basic as well as Excel was used to visualize the selected literature.Results A total of 731 articles were included.The model animals used in studies of drug-induced cardiotoxicity were mostly rats,mice and zebrafish while the modeling agents were chiefly adriamycin,aconitine and bupivacaine.The toxicity mechanism involved oxidative stress and apoptosis.Most studies used such multi-category indicators as general indicators,histopathological indicators,and cardiac function test indicators for comprehensive evaluation.The applications were also relatively concentrated,and there were great differences in the criteria for evaluating drug-induced cardiotoxicity models.Conclusion Research on drug-induced cardiotoxicity models remains promising,which can facilitate systematic development of Traditional Chinese Medicine for the prevention and treatment of drug-induced cardiotoxicity.
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