Objective To analyze the incidence of adverse drug reactions of vancomycin so as to provide reference for clinical safety warning,reduce the risk and ensure rational drug use.Methods Reports of adverse drug reactions by our hospital between 2017 and 2023 were collected and analyzed using Excel 2016.Results A total of 1 023 cases of adverse drug reactions were collected and reported in our hospital in the past 7 years Among these cases,71 were caused by vancomycin,only one was determined as"serious",and the rest were"mild".Male patients outnumbered female ones,and the age of these patients mostly ranged from 18 to 65.In 81.69%of the cases,the daily dose was 2 g.The primary diseases included infections caused by fractures,artificial joint replacement,osteomyelitis,multiple injuries,skin injuries and burns.Nearly 45.07%of the patients with adverse drug reactions showed different reactions on the day of infusion,and 34.38%developed pruritus,rash,flushing,red man syndrome,headache,and stomach discomfort within 1h.The dominating adverse reaction after 7 days was hemopenia.Conclusion Vancomycin is the drug that has induced the largest number of adverse reactions in our hospital.The vulnerable gender and age group deserve more attention.The daily dose should be standardized and blood concentration should be monitored.Pharmacists should inform patients of possible adverse reactions and formulate targeted medication plans while nurses should closely monitor patients'conditions during infusion.
关键词
万古霉素/不良反应/发生因素/安全警示/降低风险/合理用药/骨科
Key words
vancomycin/adverse reactions/cause/safety warning/risk reduction/rational drug use
维普
万方数据