Drug-Induced Thrombocytopenia(DITP)is the most common secondary thrombocytopenia in clinical practice.Based on the pathogenic mechanism,thrombocytopenia can be divided into two major categories:non-immune-mediated and drug-induced immune thrombocytopenia(DIIT).The latter is again classified into four categories based on different immune-mediated mechanisms.In addition to the classical pathway of drug-induced immune thrombocytopenia caused by drug-dependent platelet-reactive antibodies(DDAbs)binding to platelets,other categories include heparin-induced thrombocytopenia(HIT)and immune checkpoint inhibitors-induced thrombocytopenia(ICI-ITP).With the intensified development of vaccines and mass vaccinations following the global COVID-19 pandemic,a newly emerged category within DITP is vaccine-induced thrombotic thrombocytopenia(VITT).This article,in conjunction with related literature published in recent years,reviews the pathogenic characteristics and diagnosis of the aforementioned types of DITP,sorts out databases related to DITP and predicts the prospects of research.
关键词
药源性血小板减少症/免疫性/半抗原/药物依赖性/肝素/疫苗/诱导/药品不良反应
Key words
drug-induced thrombocytopenia(DITP)/immune/drug-dependent/antibodies/heparin/vaccine/induced/adverse drug reactions
维普
万方数据