Objective To systematically evaluate the efficacy and safety of Lanqin oral liquid combined with antibiotics in the treatment of acute tonsillitis.Methods Literature about randomized controlled trials(RCTs)of Lanqin oral liquid in the treatment of acute tonsillitis that was published between the inception and January 1,2023 was retrieved from Cochrane Library,EMbase,PubMed,SinoMed,CNKI,Wanfang and Weipu.Two researchers independently conducted literature screening and data retrieval according to the classification criteria.The Cochrane manual was used for quality evaluation while RevMan 5.3 software was used for data analysis.Results 5 RCTs were included involving a total of 640 patients.The results of meta-analysis showed that the treatment of acute tonsillitis with oral liquid combined with antibiotics was far more effective than antimicrobials alone in terms of shortened time of sore throat relief(MD=-20.21,95%CI[-25.18,-15.24],P<0.001)(MD=-22.62,95%CI[-30.48,-14.75],P<0.001)and response rate(RR=3.07,95%CI[1.92,4.89],P<0.001).Conclusion However,due to the low quality of clinical trials,the above findings need to be confirmed by more high-quality clinical trials,and related adverse reactions deserve attention.
Lanqin oral liquidtonsillitisantibioticssystematic reviewMeta-analysiseffectivenesssafetyabatement of feversore throat
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