Objective To analyze the new adverse reaction of Wenxin Keli causing persistent hiccups.Methods A case of persistent hiccups in a 29-year-old woman taking Wenxin Keli was analyzed.The relevance of persistent hiccups to the suspected drug was evaluated,and the causes and mechanisms of persistent hiccups in the patient caused by Wenxin Keli were analyzed through a literature review.Results By correlation evaluation,this case of hiccup is most likely due to Wenxin Keli.Discontinuation measures were used,and the patient did not experience further symptoms of persistent hiccups.Conclusion Medical personnel should be vigilant and strengthen the monitoring of the adverse reaction of Wenxin Keli causing persistent hiccups.