中国药物警戒2024,Vol.21Issue(11) :1238-1242.DOI:10.19803/j.1672-8629.20240638

淫羊藿及其主要活性成分改善男性不育症的作用机制研究进展

Research Progress of Epimedium in the Treatment of Male Infertility

唐田 谭天阳 刘柘君 白雪
中国药物警戒2024,Vol.21Issue(11) :1238-1242.DOI:10.19803/j.1672-8629.20240638

淫羊藿及其主要活性成分改善男性不育症的作用机制研究进展

Research Progress of Epimedium in the Treatment of Male Infertility

唐田 1谭天阳 2刘柘君 3白雪4
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作者信息

  • 1. 中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京 100700;中国科学院北京基因组研究所,北京 100101
  • 2. 中国中医科学院西苑医院康复医学科,北京 100091
  • 3. 首都医科大学中医药学院,北京 100069
  • 4. 中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京 100700
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摘要

目的 评估淫羊藿及其主要活性成分在治疗男性不育症中的潜力,探讨其在中医药治疗中的应用前景.方法 通过系统文献回顾,分析淫羊藿及其主要活性成分在改善精子生成、保护睾丸微环境、调节性激素水平、抗氧化应激及改善性功能障碍等方面的作用.结果 淫羊藿及其主要活性成分显示出通过调节关键信号通路和改善细胞凋亡来保护生殖细胞的潜力,同时在改善性功能障碍方面也显示出积极效果.结论 淫羊藿的活性成分在治疗男性不育症方面具一定的潜力,未来研究应进一步验证其临床疗效,以促进其在男性生殖健康领域的应用.

Abstract

Objective To assess the potential of Epimedium and its active components in the treatment of male infertility and to explore their prospects in traditional Chinese medicine therapy.Methods A systematic literature review was conducted to analyze the significant effects of Epimedium and its main active components on improving spermatogenesis,protecting the testicular microenvironment,regulating sex hormone levels,combating oxidativc stress,and alleviating sexual dysfunction.Results Epimedium demonstrated the potential to protect germ cells by modulating key signaling pathways and improving apoptosis,and it also showed positive effects in improving sexual dysfunction.Conclusion The active components of Epimedium have significant potential in the treatment of male infertility.Future research should further verify their clinical efficacy to promote their application in the field of male reproductive health.

关键词

男性不育/淫羊藿/活性成分/机制/生殖/精子生成/抗氧化应激

Key words

Male Infertility/Epimedium/Active Ingredients/Mechanism/Reproductive/Spermogenesis/Antioxidant Stress

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出版年

2024
中国药物警戒
国家药品监督管理局药品评价中心(国家药品不良反应监测中心)

中国药物警戒

CSTPCD
影响因子:1.105
ISSN:1672-8629
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