Comparison of the Effects of Docetaxel and Paclitaxel Liposome Two Neoadjuvant Chemotherapy Regimens Combined with Surgery in the Treatment of Advanced Esophageal Cancer
Objective:To compare the clinical effects of paclitaxel liposome and docetaxel neoadjuvant chemotherapy combined with surgery in patients with locally advanced esophageal cancer.Methods:The clinical data of 40 patients with locally advanced esophageal cancer admitted to the Department of Thoracic and Cardiovascular Surgery,Affiliated People's Hospital of Jiangsu University from January 2013 to May 2023 were retrospectively collected.According to the different neoadjuvant chemotherapy regimens,they were divided into observation group(21 patients,paclitaxel liposome+platinum regimen)and control group(19 patients,docetaxel + platinum regimen).Both groups were treated continuously for 2 courses.The clinical efficacy,R0 resection rate,tumor marker levels[squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA)],perioperative indicators,side effects during treatment and survival during follow-up were compared between the two groups.Results:There was no significant difference in R0 resection rate,remission rate,serum CEA,SCC-Ag,intraoperative blood loss,operation time and postoperative thoracic drainage between the two groups(P>0.05).During the treatment,the incidence of allergy and leukopenia in the control group was higher than that in the observation group(P<0.05).Within 24 months of follow-up,the total survival rate of the observation group was 47.62%(10/21),and the total survival rate of the control group was 47.37%(9/19).The Log Rank test showed that there was no significant difference in the total survival time between the two groups(P>0.05).Conclusion:The therapeutic effect of paclitaxel liposome and docetaxel neoadjuvant chemotherapy combined with surgery in patients with locally advanced esophageal cancer is similar,but the side effects of paclitaxel liposome neoadjuvant chemotherapy are lower.
DocetaxelPaclitaxel liposomesNeoadjuvant chemotherapyAdvanced esophageal cancer
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