Correlation Study of Plasma Orexin A Concentration and its Influencing Factors in Alcohol-dependent Patients During Withdrawal Period
Objective:To investigate the plasma orexin-A(OXA)concentration and related influencing factors in alcohol dependent patients during withdrawal.Methods:The clinical institute alcohol withdrawal syndrome scale(CIWA-Ar),self-rating depression scale(SDS),self-rating anxiety scale(SAS),Pittsburgh sleep quality index(PSQI)and self-made drinking questionnaire were used to evaluate the withdrawal severity,anxiety and depression symptoms,sleep quality and drinking use of 86 patients with alcohol dependence.The differences of plasma OXA levels between 86 patients with alcohol dependence and 85 normal controls were compared,and the influencing factors of OXA levels in patients with alcohol dependence withdrawal period were further analyzed.Results:The level of plasma OXA in patients with alcohol dependence during withdrawal period was higher than that in normal control group(t=5.286,P<0.05),while the level of plasma OXA in patients with alcohol dependence was positively correlated with CIWA-Ar score(r=0.405,P<0.05),sleep quality(r=0.479,P<0.05),SAS(r=0.316,P<0.05)and SDS(r=0.404,P<0.05).Further multivariate analysis showed that CIWA-Ar,PSQI score and SDS were the key factors affecting plasma OXA level.Conclusion:The level of plasma OXA in patients with alcohol dependence during withdrawal is higher.Withdrawal symptoms,sleep quality,and anxiety can affect plasma OXA levels.