Effect of Tianzhi Granules Combined with Aripiprazole in Treatment of Adolescent Obsessive-compulsive Disorder
Objective:To study the effect of Tianzhi granule combined with aripiprazole in the treatment of adolescent obsessive-compulsive disorder.Methods:A total of 110 patients with adolescent obsessive-compulsive disorder admitted to our hospital from January 2020 to December 2021 were randomly divided into two groups.The control group was treated with aripiprazole alone,and the observation group was treated with Tianzhi granules on the basis of the control group.The clinical efficacy,cognitive function,obsessive-compulsive symptoms,quality of life,anxiety and serum factors[interleukin-2(IL-2),brain-derived neurotrophic factor(BDNF)and interleukin-6(IL-6)]were compared between the two groups.Results:The total effective rate of treatment in the observation group was 94.54%,which was higher than 74.54%in the control group(P<0.05).The WHOQOL-BREF score and RBANS score of the observation group were higher than those of the control group,and the HAMA score and Y-BOCS score were lower than those of the control group(P<0.05).The serum BDNF level in the observation group was higher than that in the control group,and the levels of IL-2 and IL-6 were lower than those in the control group(P<0.05).Conclusion:Tianzhi granule combined with aripiprazole is effective in the treatment of adolescent obsessive-compulsive disorder,which can improve the cognitive function,obsessive-compulsive symptoms,quality of life and anxiety of patients,and regulate the level of serum factors.It is worthy of clinical application.
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