Effect of Long-term Use of Antibiotics on Red Blood Cell Transfusion in Patients with Malignant Tumors
Objective:To investigate the effect of long-term use of antibacterial drugs on the efficacy of red blood cell infusion in patients with malignant tumors.Methods:From March 2019 to March 2021,89 patients with malignant tumors who received red blood cell infusion therapy in the Affiliated Hospital of Henan First University were selected as the study group,and 89 patients with malignant tumors who received penicillin,cefotaxime or amoxicillin infusion for at least 3 days within 2 weeks before blood transfusion were selected as the study group.89 patients with malignant tumors who did not receive antimicrobial therapy within 1 month before blood transfusion were selected as the control group.The effect of red blood cell infusion in the two groups was evaluated and the blood samples of the two groups were tested for antiglobulin test(DAT)and antimicrobial antibody before and after blood transfusion.Results:The effective rate of red blood cell transfusion in the study group was 74.56%,which was higher than 84.40%in the control group(P<0.05).The detection rates of penicillin,cefotaxime and amoxicillin drug antibodies in blood samples of the study group were higher than those of the control group(P<0.05).The positive rate of DAT test in the study group was higher than that in the control group(P<0.05),and the effect of red blood cell transfusion in patients with positive DAT test was significantly worse than that in non-positive patients(P<0.05).Conclusion:Long term use of antibacterial drugs in patients with malignant tumors may affect the effect of red blood cell transfusion.The mechanism may be that antibacterial drugs induce the body to form antibodies and sensitize red blood cells.For such patients with malignant tumors who hadbeen using antibacterial drugs for a long time,the indications for red blood cell transfusion should be carefully evaluated to avoid ineffective blood transfusion.
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