Effect of Tacrolimus Combined with Prednisone in the Treatment of Polymyositis/Dermatomyositis Complicated with Interstitial Lung Disease
Objective:To explore the clinical efficacy of tacrolimus combined with prednisone in the treatment of polymyositis/dermatomyositis with interstitial lung disease.Method:A retrospective analysis was conducted on 78 patients with polymyositis/dermatomyositis complicated with interstitial lung disease in our People's Hospital Affiliated of Quanzhou Medical College from April 2018 to April 2023.According to different treatment plans,they were divided into a control group(43 patients treated with cyclophosphamide combined with prednisone)and an observation group(35 patients treated with tacrolimus combined with prednisone).The immunological indicators[immunoglobulin(Ig)G,IgA,IgM,complement C3,complement C4],levels of inflammatory factors[interleukin-6,IL-10,C-reactive protein(CRP)],lung function indicators[percentage of forced lung capacity to expected value(FVC%pred),and percentage of carbon monoxide diffusion in the lungs(D1CO%pred)]before treatment,at 12 weeks and 24 weeks of treatment were compared between two groups,and the occurrence of adverse reactions during the medication period were recorded between the two groups.Result:IgG,IgA,IgM,IL-6,IL-10 and CRP were gradually decreased,and complement C3,complement C4,FVC%pred and D1CO%pred were gradually increased in the two groups from before treatment to 24 weeks of treatment(P<0.05),while there was no statistical significant difference between groups or interactions(P>0.05).During the treatment,the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:The combination of tacrolimus and prednisone is equivalent in improving immune function,reducing inflammatory response,and enhancing lung function in patients with polymyositis/dermatomyositis complicated with interstitial lung disease compared to the combination of cyclophosphamide and prednisone.However,the safety of the combination of tacrolimus and prednisone is higher.
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