首页|心率变异性在精神分裂症中的诊疗价值

心率变异性在精神分裂症中的诊疗价值

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精神分裂症作为全球重症精神疾病之一,死亡率和共病率高,给全球造成了巨额经济负担.因此,对于精神分裂症的早期干预至关重要.心内科常用的无创性心脏监测技术——心率变异性(heart rate variability,HRV),其反映的是机体自主神经系统的稳态变化,可用于评估患者目前的身体状态及心脏功能.研究显示,对于精神分裂症患者而言,其心率变异性普遍低于正常人,可能与精神症状严重程度相关.此外,足量抗精神病药物也可能会改变患者自主神经稳态,进而影响患者心脏功能.总之,心率变异性可作为精神分裂症的一种量化指标,在评估精神分裂症患者自主神经功能及监测药物毒性等诸多方面发挥作用.本文对HRV、精神分裂症进行概述,并对HRV的影响因素、精神分裂症患者自主神经功能失衡、HRV与精神分裂症的精神症状的关系,以及HRV与精神分裂症治疗方案相关性四个方面进行阐述,提示HRV可作为精神分裂症患者自主神经功能评估的量化特征和生物学指标.
Value of Heart Rate Variability in Diagnosis and Treatment of Schizophrenia
As one of the severe mental illnesses in the world,schizophrenia has a high mortality rate and high comorbidity rate,which has caused a huge economic burden to the world.Therefore,early intervention for schizophrenia is crucial.Heart rate variability(HRV),a non-invasive heart monitoring technology commonly used in cardiology departments,reflects the steady-state changes of the body's autonomic nervous system and can be used to evaluate the patient's current physical status and heart function.Studies have shown that for patients with schizophrenia,their heart rate variability is generally lower than that of normal people,which may be related to the severity of psychiatric symptoms.In addition,adequate doses of antipsychotic drugs may also alter the patient's autonomic homeostasis,thereby affecting the patient's cardiac function.In short,heart rate variability can be used as a quantitative indicator of schizophrenia and plays a role in many aspects such as assessing autonomic nervous function and monitoring drug toxicity in patients with schizophrenia.This article provides an overview of HRV and schizophrenia,and discusses the influencing factors of HRV,the imbalance of autonomic nervous function in patients with schizophrenia,the relationship between HRV and the psychiatric symptoms of schizophrenia,and the correlation between HRV and schizophrenia treatment plans.This paper prompts that HRV can be used as a quantitative characteristic and biological indicator for the evaluation of autonomic nervous function in patients with schizophrenia.

Heart rate variabilitySchizophreniaPredictive indictorAdverse reaction

李宁、杨真真、胡泽睿、翟金国、闵涛

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济宁医学院精神卫生学院,山东 济宁 272067

山东省戴庄医院儿童青少年科,山东 济宁 272051

山东省戴庄医院精神三科,山东 济宁 272051

山东省戴庄医院精神四科,山东 济宁 272051

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心率变异性 精神分裂症 预测指标 不良反应

济宁市重点研发计划

2021YXNS054

2024

中国药物滥用防治杂志
中国药物滥用防治协会 军事医学科学院毒物药物研究所

中国药物滥用防治杂志

影响因子:0.584
ISSN:1006-902X
年,卷(期):2024.30(4)
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