维持治疗期中年女性精神分裂症患者应用不同抗精神病药治疗方案的效果
Effect of Different Antipsychotic Treatment Regimens on Middle-aged Female Patients with Schizophrenia During Maintenance Treatment
李欣馨 1徐勋龙 2刘洁仪 3季海峰 1徐成敏4
作者信息
- 1. 上海市长宁区精神卫生中心精神科,上海 200335
- 2. 上海交通大学附属同仁医院心内科,上海 200336
- 3. 上海市疾病预防控制中心体外毒理检测与评价室,上海 200336
- 4. 山东生精神卫生中心精神科,山东济南 250014
- 折叠
摘要
目的:分析不同抗精神病药物使用方案对中年女性精神分裂症患者的影响.方法:选择2022年12月—2023年12 月上海市长宁区精神卫生中心精神科康复区长期住院的 50 例女性精神分裂症患者,根据抗精神病药物使用的组合方式分为奥氮平单一用药组和奥氮平联合阿立哌唑用药组,比较两组泌乳素、白细胞、锥体外系不良反应(EPS)、病情稳定性.结果:维持治疗期,单一用药组泌乳素水平高于联合用药组(P<0.05);两组白细胞水平比较,差异无统计学意义(P>0.05);单一用药组EPS、复发发生率与联合用药组比较,差异无统计学意义(P>0.05).结论:在维持治疗期,奥氮平联合阿立哌唑有利于降低中年女性精神分裂症患者泌乳素水平,且安全性较高.
Abstract
Objective:To analyze the effects of different antipsychotic drug use regimens on middle-aged female patients with schizophrenia.Methods:A total of 50 female schizophrenic patients hospitalized for a long time in the psychiatric rehabilitation area of Shanghai Changning Mental Health Center from December 2022 to December 2023 were selected and divided into olanzapine single group and olanzapine combined with aripiprazole group according to the combination of antipsychotic drugs.Prolactin,leukocyte,extrapyramidal adverse reactions(EPS)and disease stability were compared between the two groups.Results:In the maintenance treatment period,the level of prolactin in single drug group was higher than that in combined drug group(P<0.05).There was no significant difference in leukocyte level between the two groups(P>0.05).There was no significant difference in the incidence of EPS and relapse between the single medication group and the combined medication group(P>0.05).Conclusion:Olanzapine combined with aripiprazole can reduce prolactin levels in middle-aged female patients with schizophrenia during maintenance treatment,and it is safe.
关键词
抗精神病药物/维持治疗/中年女性/精神分裂症Key words
Antipsychotic drugs/Maintenance therapy/Middle-aged women/Schizophrenia引用本文复制引用
基金项目
上海市长宁区卫生健康委科研项目(20194Y014)
出版年
2024
NETL
NSTL
万方数据