Effect of Antibiotics On Prevention of Wound Infection in Patients with Lower Limb Fracture
Objective:To explore the preventive effect of antibiotics on wound infection of lower limb fracture.Methods:A total of 1200 patients with lower limb fracture wound infection who were treated in our hospital from January 2020 to January 2023 were randomly divided into observation group and control group,with 600 patients in each group.The control group was not treated with antibiotics,while the observation group was treated with antibiotics(intravenous injection of ceftriaxone sodium and cefazolin sodium)to prevent wound infection.The infection status,inflammatory factor levels and antibiotic prevention effects were compared between the two groups.Results:The wound infection rate in the observation group was lower than that in the control group(P<0.05).After treatment,the levels of CRP,WBC,IL-6 and IL-8 in the observation group were lower than those in the control group(P<0.05).The infection control time and average hospitalization time of the observation group were shorter than those of the control group,and the number of dressing changes was less than that of the control group(P<0.05).Conclusion:Antibiotics are effective in preventing wound infection in patients with lower limb fracture.It can reduce wound infection,inhibit the level of inflammatory factors,shorten hospitalization time and infection control time,reduce the number of dressing changes,and facilitate the recovery of the disease.
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