Effect of Edaravone Dextrorphan Combined with Atorvastatin on Cerebral Infarction
Objective:To study the effect of edaravone dextrose(ED)combined with atorvastatin(Ator)on the changes of neurological function and four coagulation indexes in patients with cerebral infarction(CI).Methods:The clinical data of 102 patients with CI in our hospital from April 2020 to September 2022 were collected and randomly divided into group B and group A,with 51 cases in each group.Group B was treated with Ator,and group A was treated with ED combined with Ator.The clinical efficacy,National Institutes of Health Stroke Scale(NIHSS),Barthel Index(BI)score,four coagulation indexes[thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB)],vascular endothelial function indexes[nitric oxide(NO),endothelin-1(ET-1)],serum neuron-specific enolase(NSE),central nervous specific protein(S100β)levels were compared between the two groups.Results:After 2 weeks of treatment,the total effective rate of group A was higher than that of group B(P<0.05).The NIHSS score of group A was lower than that of group B,and the BI score was higher than that of group B(P<0.05).PT,APTT and TT values in group A were higher than those in group B,and FIB level was lower than that in group A(P<0.05).The level of ET-1 in group A was lower than that in group B,and the level of NO was higher than that in group B(P<0.05).The levels of serum NSE and S100β in group A were lower than those in group B(P<0.05).Conclusion:ED adjuvant therapy has a significant effect on CI patients,which can effectively improve the degree of neurological impairment and daily living ability,regulate coagulation function and vascular endothelial function,and promote the recovery of the disease.
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