Pathogen Distribution and Drug Resistance Analysis of Multidrug-resistant Bacteria Infection in Patients with Severe Pneumonia
Objective:To analyze the distribution characteristics of pathogenic bacteria in patients with severe pneumonia infected with multidrug-resistant bacteria,and to explore the drug resistance of the main pathogenic bacteria.Methods:The data of 120 patients with severe pneumonia and multidrug-resistant bacteria infection admitted to the hospital from January 2019 to December 2023 were retrospectively analyzed.All patients received sputum culture and drug sensitivity test of sputum specimens,and the results of sputum culture and drug sensitivity test were analyzed.Results:In this study,154 strains of multidrug-resistant bacteria were detected,of which Gram-negative bacteria accounted for 72.08%(111/154).Acinetobacter baumannii had the highest resistance to piperacillin-tazobactam and piperacillin,and was most sensitive to colistin and cefodil.Pseudomonas aeruginosa had the highest resistance to imipenem and the most sensitive to colistin.Klebsiella pneumoniae had the highest resistance to cefoperazone-sulbactam and levofloxacin,and was most sensitive to colistin and cefodil.The resistance rate of Staphylococcus aureus to penicillin and erythromycin was relatively high,among which penicillin had the highest resistance rate,and it was sensitive to vancomycin,fosfomycin,rifampicin,oxacillin,teicoplanin,tigecycline,norvancomycin and other drugs.Conclusion:The pathogenic bacteria of multidrug-resistant bacteria infection in patients with severe pneumonia were mainly Gram-negative bacteria.Moreover,the drug resistance to antibiotics is generally high.Clinically,the detection of drug resistance of main pathogenic bacteria should be strengthened,and drugs with higher sensitivity should be selected in a targeted manner to enhance the therapeutic effect.
Severe pneumoniaMultidrug-resistant bacteria infectionDistribution of pathogenic bacteriaDrug resistance
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