Effect of Cinacalcet Assisted Calcitriol in the Treatment of Patients with Secondary Hyperparathyroidism
Objective:To investigate the effect of cinacalcet assisted calcitriol combined with cinacalcet in the treatment of patients with secondary hyperparathyroidism(SHPT).Methods:A total of 98 patients with SHPT caused by long-term hemodialysis admitted to our hospital from June 2020 to December 2021 were selected and divided into a control group and an observation group according to the random number table method,with 49 cases in each group.The control group was treated with calcitriol,and the observation group was treated with low-dose calcitriol combined with cinacalcet.The blood calcium,blood phosphorus,calcium-phosphorus product,serum total alkaline phosphatase(ALP),serum intact parathyroid hormone(iPTH),bone mineral density,kidney disease quality of life short form(KDQOL-SF)score and adverse reactions were compared between the two groups before and after treatment.Results:After treatment,the levels of blood calcium,blood phosphorus,calcium-phosphorus product,serum ALP and iPTH in the observation group were lower than those in the control group,and the level of bone mineral density and KDQOL-SF score were higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion:Low-dose calcitriol combined with cinacalcet is effective in the treatment of SHPT,which can effectively reduce iPTH levels,maintain calcium,phosphorus and bone metabolism balance,and has good safety,which is helpful to improve the quality of life of patients.
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