Study of Targeting Dopamine D3 Receptor in the Treatment of Schizophrenia
The occurrence of schizophrenia is related to the dysfunction of dopamine in the brain.In recent years,the role of dopamine D3 receptor in schizophrenia has attracted extensive clinical attention.Preclinical and clinical studies have shown that some dopamine selective D3 receptor antagonists and some agonists have obvious therapeutic effects on negative symptoms and cognitive impairment of schizophrenia.Compared with dopamine D2 receptor,the distribution of dopamine D3 receptor in the brain is relatively limited,and drugs targeting D3 receptor are less likely to cause side effects such as extrapyramidal reactions.Therefore,D3 receptor is expected to become a new target for the treatment of neuropsychiatric diseases,which also indicates that these complex mental diseases may be treated more effectively in the future.This article summarizes the dopamine D3 receptor and the mechanism of D3 receptor dysfunction in the context of the dopamine hypothesis of schizophrenia,in order to provide a reference for clinical treatment.
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