Effects of Different Intraoperative Sedation Methods of Dexmedetomidine and Propofol on Postoperative Delirium in Elderly Patients Undergoing Hip Replacement
Objective:To explore the effect of different intraoperative sedation methods of dexmedetomidine and propofol on postoperative delirium in elderly patients undergoing hip replacement surgery.Methods:A total of 118 elderly patients who underwent elective hip replacement surgery for hip fractures under lumbar epidural anesthesia at Tianjin Hospital from January 2021 to August 2022 were included.They were divided into two groups based on different sedative drugs during surgery:the dexmedetomidine group(D group,n=59)and the propofol group(P group,n=59).The clinical parameters of the two groups were compared.Results:There was no significant difference in operation time,anesthesia time,bleeding volume,ephedrine dosage,norepinephrine dosage and atropine dosage between the two groups(P>0.05).The incidence of postoperative delirium in group D was lower than that in group P(P<0.05).There was no difference in MAP and HR between the two groups before sedation,while MAP in group D was higher than that in group P after 30 min of sedation,MAP in PACU was lower than that in group P,and HR in group D was lower than that in group P after 30 min of sedation and in PACU(P<0.05).Conclusion:For elderly patients undergoing elective hip replacement under combined spinal-epidural anesthesia,the sedative effect of intraoperative dexmedetomidine is better than that of propofol,which can reduce the incidence of postoperative delirium and stabilize intraoperative hemodynamic changes.
DexmedetomidinePropofolPostoperative deliriumHip fracture in the older patients
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