Effect of Dexmedetomidine Combined with Ketorolac Tromethamine Preemptive Analgesia on Anesthesia in Patients Undergoing Laparoscopic Cholecystectomy
Objective:To investigate the effects of dexmedetomidine ketorolac tromethamine preemptive analgesia on the quality of anesthesia recovery,analgesia,sedation and stress response in patients undergoing laparoscopic cholecystectomy(LC).Methods:A total of 80 LC patients admitted to the Third People's Hospital of Puyang from January 2020 to December 2022 were selected and divided into routine group and combined group according to the random number table method,with 40 patients in each group.The routine group was given ketorolac tromethamine for preemptive analgesia before routine anesthesia,and the combined group was given dexmedetomidine combined with ketorolac tromethamine for preemptive analgesia before routine anesthesia.The quality of anesthesia recovery,sedation at different time points after operation[Ramsay sedation scale score(RSS)],analgesic effect[visual analogue scale(VAS)],stress response[insulin-like growth factor-1(IGF-1),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6]and adverse reactions were compared between the two groups.Results:The extubation,recovery time,spontaneous breathing and directional force recovery time in the combined group were shorter than those in the routine group(P<0.05).At 6 h and 12 h after operation,the RSS score of the combined group was higher than that of the conventional group,and the VAS score was lower than that of the routine group(P<0.05).At 6 h after operation,the serum IGF-1 level in the combined group was higher than that in the routine group,and the serum TNF-α,IL-1β and IL-6 levels were lower than those in the routine group(P<0.05).After awakening,there was no significant difference in the incidence of adverse reactions between the combined group(7.50%)and the routine group(12.50%)(P>0.05).Conclusion:Dextrmetomidine combined with ketorolac tromethamine for preemptive analgesia during LC surgery has a good analgesic and sedative effect,which can reduce postoperative stress reactions,improve the quality of anesthesia and recovery,and has fewer adverse reactions,with high safety.