Effect Observation of Recombinant Tissue Plasminogen Activator in the Treatment of Myocardial Infarction Complicated with Ventricular Arrhythmia
Objective:To explore the efficacy of recombinant tissue plasminogen activator in the treatment of myocardial infarction complicated with ventricular arrhythmia and its effect on inflammatory factors.Methods:A total of 74 patients with myocardial infarction complicated with ventricular arrhythmia who were treated in our hospital from February 2021 to February 2023 were selected and divided into control group and observation group by random number table method,with 37 patients in each group.The control group was treated with urokinase,and the observation group was treated with recombinant tissue plasminogen activator.Heart rate(HR),blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)],serum N-terminal B-type natriuretic peptide precursor(NT-proBNP),vascular endothelium[serum nitric oxide(NO),von Willebrand factor(vWF),endothelin(ET-1)],cardiac function[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVSED),left ventricular ejection fraction(LVEF)],serum inflammatory factors[interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α)],oxidative stress[malondialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GPX)]were compared between the two groups.Results:After treatment,the levels of HR,SBP,DBP,NT-proBNP,vWF,ET-1,LVEDD,LVSED,IL-6,hs-CRP,TNF-α and MDA in the observation group were lower than those in the control group,and the levels of NO,LVEF,SOD and GPX were higher than those in the control group(P<0.05).Conclusion:Recombinant tissue plasminogen activator is effective in the treatment of patients with myocardial infarction complicated with ventricular arrhythmia,which can reduce heart rate,blood pressure,serum N-terminal B-type natriuretic peptide precursor level,improve vascular endothelial function,cardiac function,oxidative stress status,and reduce inflammatory factor levels.
NETL
NSTL
万方数据
