Efficacy of Moluodan Combined with Cimetidine in the Treatment of Stress Ulcer and its Effect on Serum COX-2 and HIF-1α Levels
Objective:To explore the clinical effect of Moluodan combined with cimetidine in the treatment of stress ulcer.Methods:A total of 92 patients with stress ulcer diagnosed and treated in Gucheng County People's Hospital from January 2023 to July 2023 were divided into control group and experimental group by random number table method,with 46 patients in each group.The control group was treated with cimetidine,and the experimental group was treated with moluodan combined with cimetidine.The overall efficacy,disease-related indicators and serum cyclooxygenase-2(COX-2)and hypoxia-inducible factor-1α(HIF-1α)levels were compared between the two groups after treatment.Results:After treatment,the total effective rate of the experimental group was 93.48%,which was higher than 78.26%of the control group(P<0.05).The pH value of the experimental group was higher than that of the control group,and the abdominal pain score and black stool volume were lower than those of the control group(P<0.05).The levels of serum COX-2 and HIF-1α in the experimental group were lower than those in the control group(P<0.05).Conclusion:Moluodan combined with cimetidine in the treatment of stress ulcer can obtain the exact gain effect,promote the improvement of the disease,and reduce the levels of serum COX-2 and HIF-1α.
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