Effect of rhBNP Combined with Dobutamine in the Treatment of Patients with Acute Myocardial Infarction Complicated with Cardiogenic Shock
Objective:To explore the effect of rhBNP combined with dobutamine in the treatment of patients with acute myocardial infarction complicated with cardiogenic shock.Methods:The medical records of 96 patients with acute myocardial infarction complicated with cardiogenic shock admitted to our hospital from May 2019 to May 2021 were retrospectively analyzed.According to the types of drugs used,they were divided into control group(n=48)and study group(n=48).The control group was treated with dobutamine alone,and the study group was treated with rhBNP on the basis of the control group.Myocardial injury markers(cTn-I,troponin,BNP,brain natriuretic peptide)and cardiac function indicators(LVEF,left ventricular ejection fraction,LVEDD,left ventricular end-diastolic diameter,CI,cardiac index,SV,cardiac volume)were compared between the two groups.At the same time,the incidence of adverse reactions(nausea and vomiting,skin itching,drowsiness)during the treatment of the two groups of patients was recorded,and the incidence of cardiovascular adverse events(arrhythmia,heart failure,recurrent myocardial infarction,sudden cardiac death)was followed up for half a year.Results:After intervention,the levels of cardiac cTn-I and BNP in the study group were lower than those in the control group,and LVEF,LVEDD,CI and SV were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the control group and the study group(P>0.05).The total effective rate of treatment in the study group was 95.83%,which was higher than 83.33%in the control group(P<0.05).The incidence of cardiovascular adverse events in the study group was 4.17%,which was lower than 16.67%in the control group(P<0.05).Conclusion:The combination of rhBNP and dobutamine has a good clinical effect in the treatment of acute myocardial infarction complicated with cardiogenic shock,which can effectively improve the cardiac function of patients,reduce the incidence of cardiovascular adverse events,and does not increase adverse drug reactions,with higher drug safety.
NETL
NSTL
万方数据
