Effect Comparison of Different Administration Methods of Progesterone Soft Capsule in the Treatment of Perimenopausal Dysfunctional Uterine Bleeding
Objective:To analyze the effect of different administration methods of progesterone soft capsules in the treatment of perimenopausal functional uterine bleeding.Methods:A total of 90 patients with perimenopausal functional uterine bleeding treated in our hospital from December 2019 to December 2020 were taken as research objects and divided into experimental group and reference group by random number table method,with 45 patients in each group.All patients were treated with progesterone soft capsules,in which the control group received oral administration and the experimental group received vaginal administration.The therapeutic effect,sex hormone levels,menstrual conditions,blood indexes and recurrence of the two groups were compared.Results:The total effective rate of the experimental group was 97.78%,which was higher than 86.67%of the control group(P<0.05).After treatment,the duration of menstruation in experimental group was shorter than that in reference group,and the amount of menstruation was less than that in reference group(P<0.05).After treatment,the levels of bFGF,VEGF and hemoglobin in the experimental group were higher than those in the reference group,and the score of PBC was lower than that in the reference group(P<0.05).The levels of FSH,LH,E2 and P in the experimental group were lower than those in the control group(P<0.05).The recurrence rate of the experimental group was 2.22%,which was lower than 13.33%of the control group(P<0.05).Conclusion:Progesterone soft capsule has a significant effect in patients with perimenopausal dysfunctional uterine bleeding,and the curative effect of vaginal administration is better than that of oral administration.Meanwhile,it can significantly improve the level of sex hormones and menstruation,regulate the levels of bFGF and VEGF,reduce the recurrence rate of disease,and has ideal medication value.
Progesterone soft capsuleMode of administrationPerimenopausalFunctional uterine bleedingRecurrence
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