Effect of Ivabradine Combined with Sacubitril Valsartan in the Treatment of Patients with Heart Failure and Hypertension
Objective:To analyze the effect of ivabradine combined with sacubitril valsartan in the treatment of heart failure complicated with hypertension.Methods:A total of 126 patients with heart failure combined with hypertension admitted to our hospital from January 2021 to January 2023 were divided into single drug group and combined group,with 63 patients in each group.The combined group was treated with ivabradine on the basis of the single drug group,and the single drug group was treated with sacubactrivalsa.Cardiac function,blood pressure,fibroblast growth factor 2(FGF2),hydroxy eicosatetraenoic acid(HETEs),interleukin-6(IL-6),pentamerin 3(PTX3),incidence of adverse reactions and clinical efficacy were compared between the two groups.Results:The levels of left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)after treatment were lower than before treatment,and the level of left ventricular ejection fraction(LEVF)was higher than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The levels of IL-6 and HETEs after treatment were lower than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The levels of diastolic blood pressure and systolic blood pressure after treatment were lower than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The levels of FGF2 and PTX3 after treatment were lower than before treatment,and those in the combined group were better than those in the single drug group(P<0.05).The total effective rate of combined group was higher than that of single drug group(P<0.05).The incidence of adverse reactions in combined group was higher than that in single drug group,but the difference was not statistically significant(P>0.05).Conclusion:Ivabradine combined with sacubactril valsartan can improve the blood pressure of patients with heart failure complicated with hypertension,and promote therecovery of cardiac function,with ideal effect.
IvabradineSacubatrol valsartanHeart failureHigh blood pressureReduce pressureCardiac function
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