Effect of Celecoxib Combined with Mecobalamin in the Treatment of Lumbar Disc Herniation
Objective:To analyze the effect of celecoxib combined with mecobalamin on analgesia and lumbar function in patients with lumbar disc herniation.Methods:A total of 82 patients with lumbar disc herniation admitted to our hospital from April 2022 to January 2024 were selected as the research objects.They were divided into observation group and control group by random number table method,with 41 patients in each group.The control group was treated with mecobalamin,and the observation group was treated with mecobalamin+celecoxib.The clinical efficacy,lumbar function,serum inflammatory factors and pain degree were compared between the two groups.Results:The clinical effective rate of the observation group was 91.84%,which was higher than 73.47%of the control group(P<0.05).After treatment and during follow-up,the JOA score of the observation group was higher than that of the control group,and the ODI score was lower than that of the control group(P<0.05).After treatment,the scores of PRI,VAS and PPI in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of TNF-α,IL-6 and IL-1 in the observation group were lower than those in the control group(P<0.05).Conclusion:For patients with lumbar disc herniation,mecobalamin combined with celecoxib treatment can effectively improve the lumbar function of patients,and reduce the degree of pain and serum inflammatory factor levels,which is conducive to its recovery.
CelecoxibCobamamideLumbar disc herniationAnalgesiaLumbar function
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