摘要
目的:研究多索茶碱联合头孢哌酮舒巴坦钠治疗重症肺炎患者的效果.方法:以 2021 年 9 月—2023 年 1 月我院收治的 115 例重症肺炎患者为研究对象,采用随机数字表法分为对照组(57 例)、联合组(58 例).对照组采用头孢哌酮舒巴坦钠治疗,联合组在此基础上联合多索茶碱治疗.比较两组临床疗效、治疗前后肺功能指标[呼气峰值流速(PEF)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]、血气指标[动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、血氧饱和度(SaO2)]、外周血Treg/Th17 水平(Treg细胞数、Th17 细胞数、Treg/Th17)、外周血白细胞介素-17(IL-17)、IL-10水平.结果:联合组治疗总有效率为98.28%,高于对照组的85.96%,差异有统计学意义(P＜0.05);联合组治疗后PEF、FVC、FEV1、FEV1/FVC高于对照组,差异有统计学意义(P＜0.05);联合组治疗后PaO2、SaO2 高于对照组,PaCO2 低于对照组,差异有统计学意义(P＜0.05);联合组治疗后外周血Treg细胞、Treg/Th17、IL-10 水平低于对照组,差异有统计学意义(P＜0.05).结论:联合多索茶碱治疗重症肺炎效果显著,能有效改善患者血气指标及肺功能,还有利于减轻炎症反应,调节机体免疫.
Abstract
Objective:To study the effect of doxofylline combined with cefoperazone sulbactam sodium in the treatment of patients with severe pneumonia.Methods:A total of 115 patients with severe pneumonia admitted to our hospital from September 2021 to January 2023 were enrolled in the study.They were divided into control group(57 cases)and combined group(58 cases)by random number table method.The control group was treated with cefoperazone sulbactam sodium,and the combined group was treated with doxofylline on this basis.The clinical efficacy,lung function indexes[peak expiratory flow(PEF),forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),FEV1/FVC],blood gas indexes[arterial partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),oxygen saturation(SaO2)],peripheral blood Treg/Th17 levels(Treg cell count,Th17 cell count,Treg/Th17),peripheral blood interleukin-17(IL-17)and IL-10 levels were compared between the two groups before and after treatment.Results:The total effective rate of treatment in the combined group was 98.28%,which was higher than 85.96%in the control group,and the difference was statistically significant(P＜0.05).PEF,FVC,FEV1 and FEV1/FVC in the combined group were higher than those in the control group,and the differences were statistically significant(P＜0.05).PaO2 and SaO2 in the combined group were higher than those in the control group,and PaCO2 was lower than that in the control group(P＜0.05).The levels of peripheral blood Treg cells,Treg/Th17 and IL-10 in the combined group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion:The combination of doxofylline in the treatment of severe pneumonia has a significant effect,which can effectively improve the blood gas index and lung function of patients,and also help to reduce the inflammatory response and regulate the body's immunity.
NETL
NSTL
万方数据