Effect of Shugan Jianpi Yishen Decoction Combined with GP Chemotherapy in the Treatment of Patients with Advanced Breast Cancer
Objective:To study the effect of Shugan Jianpi Yishen Decoction on symptom improvement and side effects in patients with advanced breast cancer undergoing chemotherapy.Methods:A total of 80 patients with advanced breast cancer admitted to our hospital from March 2021 to August 2022 were randomly divided into a control group(40 patients)and a study group(40 patients.The control group received conventional chemotherapy,while the study group received conventional chemotherapy and Shugan Jianpi Yishen Decoction.The TCM syndrome scores,tumor markers,inflammatory factors,cellular immune function,general toxic side effects,and digestive system toxic side effects were compared between the two groups.Results:After treatment,the scores of TCM syndrome indexes and the levels of carcinoembryonic antigen,cancer antigen 15-3,cancer antigen 125,high-sensitivity C-reactive protein,tumor necrosis factor-α and interleukin-6 in the study group were lower than those in the control group,while the levels of CD3+,CD4+and CD4+/CD8+were higher than those in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of bone marrow suppression,cardiotoxicity and vascular injury between the study group and the control group(P＞0.05).The severity of nausea and vomiting in the study group was lighter than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion:Shugan Jianpi Yishen Decoction can effectively improve the symptoms and immune function of patients,alleviate inflammatory reactions and digestive system toxic side effects.
Advanced breast cancerChemotherapyShugan Jianpi Yishen DecoctionClinical symptomsToxic side effects
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