Effect of Dexmedetomidine Combined with Nalbuphine on General Anesthesia in Laparoscopic Cholecystectomy and its Effect on the Recovery Period
Objective:To analyze the application value of dexmedetomidine combined with nalbuphine in the recovery period of patients undergoing laparoscopic cholecystectomy(LC).Methods:The clinical data of 110 patients with cholecystolithiasis who underwent LC in the hospital from April 2022 to April 2023 were retrospectively analyzed.According to different intraoperative anesthesia schemes,they were divided into control group and observation group,with 55 patients in each group.The control group was anesthetized with dexmedetomidine,and the study group was combined with nalbuphine anesthesia on the basis of the control group.The hemodynamic indexes[mean arterial pressure(MAP),heart rate(HR)],operation time,recovery time,extubation time and adverse reactions during hospitalization were compared between the two groups.Results:At the time of extubation,the MAP and HR of the two groups were higher than those at the end of the operation,and the MAP and HR at 10 min after extubation were higher than those at the time of extubation,showing a trend of increasing first and then decreasing.There were statistically significant differences between the two groups at the time point,between groups and interaction(P<0.05).There was no significant difference in operation time between the two groups(P>0.05).The recovery time of extubation and directional force in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.64%(2/55),which was lower than that 7.27%(4/55)in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Dexmedetomidine combined with nalbuphine can effectively stabilize the postoperative hemodynamic level of LC patients without increasing the risk of adverse reactions.
DexmetomidineNalbuphineLaparoscopic cholecystectomyRecovery Period