首页|右美托咪定联合纳布啡在腹腔镜胆囊切除术全身麻醉中的效果及对患者苏醒期的影响

右美托咪定联合纳布啡在腹腔镜胆囊切除术全身麻醉中的效果及对患者苏醒期的影响

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目的:分析右美托咪定联合纳布啡在腹腔镜胆囊切除术(LC)患者苏醒期中的应用价值.方法:回顾性分析2022 年 4 月—2023 年 4 月该院收治的 110 例行LC的胆囊结石患者的临床资料,根据术中麻醉方案不同将其分为对照组和观察组,各 55 例.对照组行右美托咪定麻醉,研究组在对照组基础上联合纳布啡麻醉,比较两组血流动力学指标[平均动脉压(MAP)、心率(HR)]、手术时间、苏醒时间、拔管时间及住院期间不良反应发生情况.结果:拔管时,两组MAP、HR高于术毕时,拔管后 10 min MAP、HR高于拔管时,呈先上升后下降趋势,两组时点、组间及交互比较,差异有统计学意义(P<0.05);两组手术时间比较,差异无统计学意义(P>0.05),观察组拔管及定向力恢复时间短于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为3.64%(2/55),低于对照组的7.27%(4/55),但差异无统计学意义(P>0.05).结论:右美托咪定联合纳布啡可有效稳定LC患者术后血流动力学水平,且不会增加患者不良反应风险.
Effect of Dexmedetomidine Combined with Nalbuphine on General Anesthesia in Laparoscopic Cholecystectomy and its Effect on the Recovery Period
Objective:To analyze the application value of dexmedetomidine combined with nalbuphine in the recovery period of patients undergoing laparoscopic cholecystectomy(LC).Methods:The clinical data of 110 patients with cholecystolithiasis who underwent LC in the hospital from April 2022 to April 2023 were retrospectively analyzed.According to different intraoperative anesthesia schemes,they were divided into control group and observation group,with 55 patients in each group.The control group was anesthetized with dexmedetomidine,and the study group was combined with nalbuphine anesthesia on the basis of the control group.The hemodynamic indexes[mean arterial pressure(MAP),heart rate(HR)],operation time,recovery time,extubation time and adverse reactions during hospitalization were compared between the two groups.Results:At the time of extubation,the MAP and HR of the two groups were higher than those at the end of the operation,and the MAP and HR at 10 min after extubation were higher than those at the time of extubation,showing a trend of increasing first and then decreasing.There were statistically significant differences between the two groups at the time point,between groups and interaction(P<0.05).There was no significant difference in operation time between the two groups(P>0.05).The recovery time of extubation and directional force in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.64%(2/55),which was lower than that 7.27%(4/55)in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Dexmedetomidine combined with nalbuphine can effectively stabilize the postoperative hemodynamic level of LC patients without increasing the risk of adverse reactions.

DexmetomidineNalbuphineLaparoscopic cholecystectomyRecovery Period

王志远、张舒依、韩孟阳、靳尧、赵林

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许昌市人民医院麻醉科手术部,河南 许昌 461000

右美托咪定 纳布啡 腹腔镜胆囊切除术 苏醒期

河南省科技发展计划项目

182102310657

2024

中国药物滥用防治杂志
中国药物滥用防治协会 军事医学科学院毒物药物研究所

中国药物滥用防治杂志

影响因子:0.584
ISSN:1006-902X
年,卷(期):2024.30(9)
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