Analysis of Adverse Drug Reactions Induced by Etimicin Based on Literature and Drug Instructions
Objective:To analyze the occurrence regularity and characteristics of adverse drug reactions(ADR)induced by etimicin and provide reference for clinical rational drug use.Methods:Case reports of ADR induced by etimicin were retrieved from CNKI,Wanfang,VIP,PubMed,and Embase(by December,2023),the safety information in the drug instructions of different marketing authorization holders were compared,the data were extracted and statistically analyzed.Results:A total of 30 literatures were collected,involving 33 patients.The ratio of male to female was about 1∶1.The age was 40-49 years old(24.24%),50-59 years old(18.18%)and 60-69 years old(18.18%).There were 6 cases(18.18%)with a history of drug allergy.The daily dosage was 0.05-0.3 g,and most of the dosage forms were injection(63.63%).The occurrence time of ADR was mostly within 30 min(60.61%),mainly involving systemic damage(31.58%),central and peripheral nervous system damage(24.56%),skin and its appendages damage(10.53%).The drug instructions of each holder were inconsistent,and the relevant safety information,especially the ADR description,was too simple.Conclusion:Etimicin can induce a variety of ADR which are not described in the instructions,involving multiple systems/organs.The instructions should be improved and updated in time.The clinical application of etimicin should be strictly in accordance with the drug instructions.It is necessary to strengthen drug monitoring,prepare emergency medicine,identify ADR and give symptomatic treatment as soon as possible to ensure the safety of patients'medication.
EtimicinAdverse drug reactionLiterature analysisDrug instruction
NETL
NSTL
万方数据
