Comparison of the Effects of Different Administration Methods of Azithromycin in the Treatment of Children with Respiratory Tract Infection
Objective:To investigate the effect of different azithromycin administration in the treatment of children with respiratory tract infection.Methods:A total of 80 children with respiratory tract infection who were treated with azithromycin in the Department of Pediatrics of our hospital from February 2022 to January 2023 were randomly divided into two groups.The observation group was given intravenous azithromycin for 3 days,followed by withdrawal for 4 days,and then oral azithromycin dry suspension for 3 days(n=40),while the control group was given intravenous injection for 7 days(n=40).The clinical efficacy,inflammatory factor levels(CRP,IL-6,IL-8),symptom resolution time(sputum,cough,fever,lung rarities)and adverse reactions(gastrointestinal reactions,arrhythmia,fever,allergic rash)were compared between the two groups.Results:The remission time of main symptoms,clinical effect,incidence of adverse reactions and levels of inflammatory factors in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Azithromycin administered by intravenous drip before oral administration not only has better clinical efficacy than intravenous injection in the treatment of respiratory tract infection in children,but also can more effectively reduce the level of inflammatory factors and shorten the time of symptom relief.At the same time,the incidence of adverse reactions is low,which is worthy of clinical promotion.
AzithromycinDepartment of PediatricsRespiratory infectionAdministration modeAdverse reactionsInflammatory factor
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