阿奇霉素不同给药方式治疗呼吸道感染患儿的效果对比
Comparison of the Effects of Different Administration Methods of Azithromycin in the Treatment of Children with Respiratory Tract Infection
刘颖 1孙会婷 1彭敦权 1杨媛芬1
作者信息
- 1. 濮阳油田总医院药学部,河南 濮阳 457000
- 折叠
摘要
目的:探讨阿奇霉素不同给药方式治疗呼吸道感染患儿的效果.方法:选取 2022 年 2 月—2023 年 1 月于我医院儿科接受阿奇霉素治疗的呼吸道感染患儿 80 例,随机分为两组,观察组采用静脉滴注阿奇霉素 3 d,停药 4 d,之后口服阿奇霉素干混悬剂 3d(n=40),对照组采用静脉注射 7d方式(n=40).比较两组的临床疗效、炎症因子水平(CRP、IL-6、IL-8)、症状缓解时间(痰多、咳嗽、发热、肺部啰音消失时间)以及不良反应(消化道反应、心律失常、发热、过敏性皮疹).结果:观察组各主要症状缓解时间、临床效果、不良反应发生率、炎症因子水平均优于对照组,差异有统计学意义(P<0.05).结论:阿奇霉素先静脉滴注后口服的给药方案在儿童呼吸道感染治疗中不仅具有优于静脉注射的临床疗效,而且能够更有效地降低炎症因子水平、缩短症状缓解时间,同时不良反应发生率较低,值得临床推广.
Abstract
Objective:To investigate the effect of different azithromycin administration in the treatment of children with respiratory tract infection.Methods:A total of 80 children with respiratory tract infection who were treated with azithromycin in the Department of Pediatrics of our hospital from February 2022 to January 2023 were randomly divided into two groups.The observation group was given intravenous azithromycin for 3 days,followed by withdrawal for 4 days,and then oral azithromycin dry suspension for 3 days(n=40),while the control group was given intravenous injection for 7 days(n=40).The clinical efficacy,inflammatory factor levels(CRP,IL-6,IL-8),symptom resolution time(sputum,cough,fever,lung rarities)and adverse reactions(gastrointestinal reactions,arrhythmia,fever,allergic rash)were compared between the two groups.Results:The remission time of main symptoms,clinical effect,incidence of adverse reactions and levels of inflammatory factors in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Azithromycin administered by intravenous drip before oral administration not only has better clinical efficacy than intravenous injection in the treatment of respiratory tract infection in children,but also can more effectively reduce the level of inflammatory factors and shorten the time of symptom relief.At the same time,the incidence of adverse reactions is low,which is worthy of clinical promotion.
关键词
阿奇霉素/儿科/呼吸道感染/给药方式/不良反应/炎症因子Key words
Azithromycin/Department of Pediatrics/Respiratory infection/Administration mode/Adverse reactions/Inflammatory factor引用本文复制引用
基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20191375)
出版年
2024
NETL
NSTL
万方数据