促红素辅助常规疗法对肾衰竭血液透析患者铁代谢水平及微炎症状态的影响
Effects of Erythropoietin-Assisted Conventional Therapy on Iron Metabolism and Microinflammatory State in Hemodialysis Patients with Renal Failure
李明凤 1刘宗旸 1包敏 1涂显敏 1代玉娇 1姜燕2
作者信息
- 1. 印江土家族苗族自治县人民医院肾内科/血液透析室,贵州 铜仁 555200
- 2. 贵州医科大学附属肿瘤医院肾内科,贵州 贵阳 550003
- 折叠
摘要
目的:探究促红素对肾衰竭血液透析患者铁代谢水平及微炎症状态的影响.方法:随机选取 2023 年 1 月—2024 年 1 月印江土家族苗族自治县人民医院收治的肾衰竭血液透析患者60 例作为研究对象,按照数字表法分成常规组和促红素组,每组30例.常规组接受常规治疗,促红素组在常规治疗基础上接受促红素治疗,比较两组治疗前后铁代谢水平、炎症因子变化、不良反应发生率.结果:治疗后,促红素组sTfR、IL-6、hs-CRP、TNF-α较常规组降低,SF、TAST均较常规组升高(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:促红素可良好改善肾衰竭血液透析患者的铁代谢水平,减轻微炎症状态,且安全性较高.
Abstract
Objective:To explore the effect of erythropoietin on iron metabolism and microinflammatory state in hemodialysis patients with renal failure.Methods:A total of 60 hemodialysis patients with renal failure admitted to the People's Hospital of Yinjiang Tujia and Miao Autonomous County from January 2023 to January 2024 were randomly selected as the research objects.According to the digital table method,they were divided into routine group and erythropoietin group,with 30 patients in each group.The routine group received routine treatment,and the erythropoietin group received erythropoietin treatment on the basis of routine treatment.The levels of iron metabolism,changes of inflammatory factors and incidence of adverse reactions were compared between the two groups before and after treatment.Results:After treatment,sTfR,IL-6,hs-CRP and TNF-α in the erythropoietin group were lower than those in the conventional group,and SF and TAST were higher than those in the routine group(P<0.05).Conclusion:Erythropoietin can improve the iron metabolism level of hemodialysis patients with renal failure,reduce the microinflammatory state,and has high safety.
关键词
促红素/肾衰竭/铁代谢/微炎症状态Key words
Erythropoietin/Renal failure/Iron metabolism/Micro-inflammatory status引用本文复制引用
基金项目
贵州省科技厅基金项目(黔科合成果-LC[2023]021)
出版年
2024
NETL
NSTL
万方数据