Effect of Dapagliflozin Combined with Metformin Sustained-release Tablets in the Treatment of Type 2 Diabetes Mellitus
Objective:To investigate the impact of Dapagliflozin combined with Metformin Hydrochloride Extended-Release Tablets on the excellent and good rate of blood glucose control,blood glucose levels,and safety in patients with type 2 diabetes mellitus.Methods:A total of 180 patients with type 2 diabetes mellitus who received treatment at our hospital from January 2021 to December 2023 were selected and randomly divided into an observation group(94 patients)and a control group(86 patients)using a random lottery method.The control group received oral administration of Metformin hydrochloride extended-release tablets alone,while the observation group received oral dapagliflozin in addition to the control group's treatment.The excellent and good rate of blood glucose control,random blood glucose,glycated hemoglobin,and the incidence of adverse reactions were compared between the two groups.Results:①The excellent and good rate of blood glucose control in the observation group(87.23%)was higher than that in the control group(72.09%),with a statistically significant difference(P<0.05).② After treatment,the observation group had lower random blood glucose and glycated hemoglobin levels compared to the control group,with statistically significant differences(P<0.05).③ There was no statistically significant difference in the incidence of adverse reactions between the observation group(8.51%)and the control group(8.14%)(P>0.05).Conclusion:The treatment of type 2 diabetes mellitus patients with dapagliflozin combined with metformin hydrochloride extended-release tablets does not result in serious adverse drug reactions.It can improve the excellent and good rate of blood glucose control and stabilize blood glucose levels in patients,making it worthy of clinical application.
NETL
NSTL
万方数据
