Comparison of the Effects of Irbesartan and Losartan Potassium Combined with Nifedipine in the Treatment of Hypertension
Objective:To investigate the therapeutic effect of irbesartan and losartan potassium combined with conventional drugs on hypertension and their effects on liver and kidney function.Methods:A total of 100 patients with essential hypertension admitted to our hospital from September 2020 to September 2023 were selected and divided into irbesartan group and losartan potassium group by random number table method,with 50 patients in each group.The irbesartan group was treated with irbesartan+nifedipine,and the losartan potassium group was treated with losartan potassium+nifedipine.The clinical efficacy,blood pressure level,liver function index and renal function index were compared between the two groups.Results:There was no significant difference in the total effective rate,SBP and DBP levels between the two groups(P>0.05).After treatment,the levels of ALP,ALT and AST in irbesartan group were lower than those in losartan potassium group(P<0.05).After treatment,the levels of SCr,BUN and uric acid in losartan potassium group were lower than those in irbesartan group(P<0.05).Conclusion:Irbesartan and losartan potassium combined with conventional drugs can improve the clinical efficacy of hypertension and reduce the level of blood pressure.However,irbesartan can improve the liver function of patients,and losartan potassium can improve the renal function of patients.Therefore,different drugs can be selected according to the degree of liver and kidney injury in patients with hypertension.
IrbesartanKlosartan potassiumHypertensionLiver functionRenal function
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