Effect of Butylphthalide Soft Capsules Combined with Yinxing Mihuan Oral Liquid in the Treatment of Vascular Dementia
Objective:To observe the curative effect of Butylphthalide Soft Capsules combined with Yinxing Mihuan oral liquid in treatment of vascular dementia.Methods:A total of 56 patients with vascular dementia who were treated in the outpatient department of Jinshui District General Hospital of Zhengzhou City and Henan Provincial Hospital of Traditional Chinese Medicine from June 2022 to February 2024 were randomly divided into clinical group and control group,with 28 patients in each group.The control group was treated with butylphthalide soft capsules,and the clinical group was treated with butylphthalide soft capsules combined with Yinxing Mihuan oral liquid.The clinical efficacy,cognitive function,living ability,blood lipid level,superoxide dismutase(SOD)activity,hemorheology indexes and adverse reactions were compared between the two groups.Results:The total effective treatment rate of the clinical group was 92.86%,which was higher than 82.14%of the control group(P<0.05).After treatment,the scores of MMSE and ADL in the clinical group were higher than those in the control group(P<0.05).After treatment,the levels of TG,TC and LDL-C in the clinical group were lower than those in the control group,and the activities of HDL-C and SOD were higher than those in the control group(P<0.05).After treatment,the whole blood low shear viscosity,whole blood middle shear viscosity,whole blood high shear viscosity and fibrinogen in the clinical group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Butylphthalide soft capsule combined with Yinxing Mihuan oral liquid is effective in the treatment of vascular dementia.It can improve the cognitive function and daily living ability of patients,reduce blood lipid level,improve SOD activity,regulate hemorheological parameters,and has high safety.
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