Clinical Study on Compound Gegen Qinlian Decoction Combined with Prednisone in the Treatment of Pulmonary Fibrosis
Objective:To study the curative effect of compound Gegen Qinlian decoction combined with prednisone on pulmonary fibrosis.Methods:A total of 70 patients with pulmonary fibrosis admitted to our hospital from January 2021 to December 2023 were randomly divided into control group and observation group,with 35 cases in each group.The control group was treated with prednisone,and the observation group was treated with compound Gegen Qinlian decoction combined with prednisone.The symptom scores,lung function[maximum expiratory pressure(PEmax),forced vital capacity(FVC),peak expiratory flow(PEF),carbon monoxide diffusion(DLCO),maximum inspiratory pressure(PImax)]and inflammatory factors[serum tumor necrosis factor-α(TNF-α),transforming growth factor-β(TGF-β)]were compared between the two groups.Results:After treatment,the scores of dyspnea,cough,fatigue,cyanosis and expectoration in the observation group were lower than those in the control group(P<0.05).The PEmax,FVC,PEF,DLCO and PImax in the observation group were higher than those in the control group(P<0.05).The levels of serum TNF-α and TGF-β in the observation group were lower than those in the control group(P<0.05).Conclusion:Compound Gegen Qinlian decoction combined with prednisone can significantly reduce the symptoms of patients with pulmonary fibrosis and improve their lung function.The mechanism may be related to the down-regulation of TGF-β level.
Compound Gegen Qinlian decoctionPrednisonePulmonary fibrosisTumor necrosis factor-αTransforming growth factor-β
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