首页|益气养阴汤辅助紫杉醇联合顺铂化疗方案治疗卵巢癌的效果观察及对患者3年生存情况的影响

益气养阴汤辅助紫杉醇联合顺铂化疗方案治疗卵巢癌的效果观察及对患者3年生存情况的影响

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目的:探讨益气养阴汤联合紫杉醇+顺铂方案对卵巢癌患者身体状态及血清糖类抗原 125 和CEA的影响.方法:将本院 2018 年 1 月—2020 年 12 月收治的 84 例卵巢癌患者按照入院先后顺序进行编号,单号为对照组(n=42)给予紫杉醇+顺铂化疗,双号为治疗组(n=42)在对照组基础上联合益气养阴汤治疗.对比两组近期疗效、毒副反应、健康状况、血清CA-125 和CEA表达情况以及3 年生存情况.结果:治疗组总有效率为57.14%,与对照组的50.00%比较,差异无统计学意义(P>0.05);治疗组毒副反应发生率低于对照组(P<0.05);治疗组治疗后KPS评分高于对照组(P<0.05);治疗组治疗后血清CA-125 和CEA表达水平低于对照组(P<0.05);治疗组 3 年生存率为 59.52%,高于对照组的 38.10%(P<0.05);治疗组无进展生存时间高于对照组(P<0.05).结论:对卵巢患者采取益气养阴汤联合紫杉醇+顺铂化疗方案进行治疗可获得良好的疗效,有效减少患者毒副反应,并延长其生存期.
Observation on the Effect of Yiqi Yangyin Decoction Combined with Paclitaxel Combined with Cisplatin Chemotherapy in the Treatment of Ovarian Cancer and its Effect on 3-year Survival
Objective:To investigate the effects of Yiqi Yangyin decoction combined with paclitaxel+cisplatin regimen on physical status and serum carbohydrate antigen 125 and CEA in patients with ovarian cancer.Methods:A total of 84 patients with ovarian cancer admitted to our hospital from January 2018 to December 2020 were numbered according to the order of admission.The single number was the control group(n=42)treated with paclitaxel+cisplatin chemotherapy,and the double number was the treatment group(n=42)treated with Yiqi Yangyin decoction on the basis of the control group.The short-term efficacy,toxic and side effects,health status,serum CA-125 and CEA expression and 3-year survival were compared between the two groups.Results:The total effective rate of the treatment group was 57.14%,which was compared with 50.00%of the control group,the difference was not statistically significant(P>0.05).The incidence of toxic and side effects in the treatment group was lower than that in the control group(P<0.05).After treatment,the KPS score of the treatment group was higher than that of the control group(P<0.05).The expression levels of serum CA-125 and CEA in the treatment group were lower than those in the control group(P<0.05).The 3-year survival rate of the treatment group was 59.52%,which was higher than 38.10%of the control group(P<0.05).The progression-free survival time of the treatment group was higher than that of the control group(P<0.05).Conclusion:The treatment of ovarian patients with Yiqi Yangyin decoction combined with paclitaxel+cisplatin chemotherapy can achieve good curative effect,effectively reduce the toxic and side effects of patients,and prolong their survival.

Yiqi Yangyin decoctionPaclitaxel+cisplatin chemotherapyOvarian cancerCA-125

秦园园、汪文录、张贝贝、周丽君

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河南省第二人民医院肿瘤科,河南 新郑 451191

河南省第二人民医院骨科,河南 新郑 451191

益气养阴汤 紫杉醇+顺铂化疗 卵巢癌 CA-125

河南省医学科技攻关计划联合共建项目

LHGJ20220483

2024

中国药物滥用防治杂志
中国药物滥用防治协会 军事医学科学院毒物药物研究所

中国药物滥用防治杂志

影响因子:0.584
ISSN:1006-902X
年,卷(期):2024.30(9)
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