The Stability and Divided Dose Study of Extemporaneous Ibuprofen Suspension
Objective:To investigate the stability and the accuracy of divided dose of extemporaneous ibuprofen suspension. Methods:In the experiment,tablets were crushed into powder and added to single syrup and pure water to make suspension respectively. Stability test and divided dose test were carried out respectively to investigate the drug stability and divided dose accuracy at 0,4,8,24 hours at room temperature and refrigerator (2 ℃-10 ℃). Results:In the stability test,the concentrations of the two suspensions were both within the range of 98.1％-100.7％ of the initial concentration after 72 h. In the divided dose test,at refrigerator (2 ℃-10 ℃),there was no significant difference between 0 h and 4 h when single syrup was used as the solvent,and there was significant difference at all other periods. There were significant differences between most periods when purified water was the solvent. At room temperature,there was a significant difference between 24 h and 0 h when single syrup was used as solvent,but no significant difference in other periods. The divide dose concentrations at 4,8 and 24 h were all within the accurate range. Except that there was no significant difference between 0 h and 4 h when in pure water,there were significant differences between other periods. Conclusion:At room temperature and refrigerator(2 ℃-10 ℃),the two suspensions have good stability after 72 h. In the 24 h divided dose test,the dose is relatively accurate only when the single syrup is used as the solvent at room temperature and the storage time is at least 24 h.
万方数据
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