Effect of Mifepristone Combined with Leuprorelin in the Treatment of Uterine Fibroids
Objective:To study the effect of the combination of mifepristone and leuprorelin on uterine fibroids. Methods:Eighty patients with uterine fibroids who visited our hospital from January 2021 to December 2023 were selected as the research subjects. They were randomly divided into a control group and an observation group using a lottery method,with 40 patients in each group. The control group received mifepristone alone,while the observation group received leuprorelin in addition. Compare the clinical efficacy,symptom scores,sex hormone levels,and serum factors[insulin-like growth factor-l (IGF-1),matrix metalloproteinase-9 (MMP-9),tumor necrosis factor-α (TNF-α),vascular endothelial growth factor (VEGF),high-sensitivity C-reactive protein (hs CRP)]between two groups. Results:After treatment,the effective rate of the observation group was higher than that of the control group (P<0.05). The scores of lassitude,breast distending pain,menorrhagia,abdominal distending pain and prolonged menstrual period in the observation group were lower than those in the control group (P<0.05). The levels of serum LH,E2,FSH and P in the observation group (P<0.05). The levels of IGF-1,MMP-9,TNF-α,VEGF and hs-CRP in the observation group were lower than those in the control group (P<0.05). Conclusion:Mifepristone combined with leuprorelin can improve the efficacy of uterine fibroids,reduce their symptoms and improve sex hormone levels. The mechanism may be related to the down-regulation of serum IGF-1,MMP-9,TNF-α,VEGF and hs-CRP levels.
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