Effect of Neoadjuvant Chemotherapy Combined with Laparoscopic Radical Gastrectomy in the Treatment of Advanced Gastric Cancer
Objective:To investigate the effect of neoadjuvant chemotherapy combined with laparoscopic radical resection in the treatment of advanced gastric cancer. Methods:A total of 117 patients with advanced gastric cancer from August 2018 to June 2023 were selected and divided into two groups according to different treatment methods. Among them,58 patients of the control group received laparoscopic radical gastrectomy,and 59 patients of the observation group received laparoscopic radical gastrectomy after neoadjuvant chemotherapy. The operation-related parameters,immune function indexes,PG Ⅱ,MMP-2,MMP-9,VEGF-A levels and complications were compared between the two groups. Results:After operation,there was no significant difference in the rate of conversion to laparotomy,the incidence of complications,the number of lymph nodes dissected,intraoperative blood loss,postoperative exhaust time,operation time and drainage tube removal time between the observation group and the control group (P>0.05). The levels of CD3+and CD4+in the observation group were higher than those in the control group,and the levels of IgA,IgE,PGII,MMP-2,MMP-9 and VEGF-A were lower than those in the control group (P<0.05). Conclusion:Neoadjuvant chemotherapy combined with laparoscopic radical gastrectomy can effectively improve the immune function of patients with advanced gastric cancer,regulate the expression of PG,MMP and VEGF,and have no obvious influence on operation-related parameters and complications,so it is safe.
Neoadjuvant chemotherapyLaparoscopic radical operationAdvanced gastric cancer
万方数据
维普
