Effect of Amlodipine Besylate and Atorvastatin Calcium Tablets in the Treatment of Hypertension and its Effect on Cardiovascular Active Peptide,Arteriosclerosis and Blood Lipid Levels
Objective:To investigate the effect of amlodipine besylate and atorvastatin calcium tablets on cardiovascular active peptide and arteriosclerosis related indexes in patients with hypertension. Methods:A total of 74 patients with hypertension who were treated in the hospital from June 2022 to June 2023 were selected and divided into two groups according to the random number table method,with 37 patients in each group. The control group was treated with amlodipine besylate tablets,and the observation group was treated with amlodipine besylate and atorvastatin calcium tablets. Both groups were treated continuously for 3 months. The levels of blood pressure,cardiovascular active peptide,arteriosclerosis index and blood lipid index were compared between the two groups before treatment and 3 months after treatment. Results:After 3 months of treatment,the systolic blood pressure and diastolic blood pressure in the observation group were lower than those in the control group (P<0.05). Salusin-α and ghrelin in the observation group were higher than those in the control group,and Salusin-β was lower than that in the control group (P<0.05). The brachial ankle pulse wave velocity (BaPWV) and homocysteine (Hcy) in the observation group were lower than those in the control group,and the ankle brachial index (ABI) was higher than that in the control group (P<0.05). The total cholesterol (TC),triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in the observation group were lower than those in the control group,and the high density lipoprotein cholesterol (HDL-C) was higher than that in the control group (P<0.05). Conclusion:Amlodipine besylate and atorvastatin calcium tablets can improve the level of cardiovascular active peptide in patients with hypertension,effectively control the level of blood lipid and control the progress of arteriosclerosis.
HypertensionAmlodipine besylate and atorvastatin calcium tabletsCardiovascular active peptidesArteriosclerosis
万方数据
维普
