Effect of Low Molecular Heparin Sodium Combined with Conventional Drugs in the Treatment of Patients with Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure
Objective:To investigate the clinical efficacy of low molecular weight heparin sodium in the treatment of chronic obstructive pulmonary disease (COPD) with respiratory failure. Methods:A total of 72 patients with COPD and respiratory failure admitted to Shangqiu First People's Hospital from April 2021 to April 2023 were randomly divided into two groups,namely the control group and the experimental group,with 36 patients in each group. The control group was given routine treatment,and the experimental group was treated with low molecular weight heparin sodium on the basis of routine treatment. Both groups were treated continuously for 10 days. The clinical efficacy,blood gas analysis indexes[arterial blood PH value,arterial partial pressure of oxygen (PaO2),arterial partial pressure of carbon dioxide (PaCO2)],lung function indexes[forced expiratory volume in one second (FEV1),forced vital capacity (FVC),peak expiratory flow rate (PEF)]and adverse reactions were compared between the two groups. Results:After treatment,the total effective rate of the experimental group was higher than that of the control group (P<0.05). The arterial blood PH value and PaO2 level in the experimental group were higher than those in the control group,and the PaCO2 level was lower than that in the control group (P<0.05). FEV1,FVC and PEF in the experimental group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion:Low molecular weight heparin sodium has good clinical efficacy in the treatment of COPD patients with respiratory failure,which can improve blood gas analysis index and lung function,and has good safety.
Chronic obstructive pulmonary diseaseRespiratory failureLow molecular weight heparin sodiumBlood gas indexLung function
万方数据
维普
