Research on Prescription Optimization and Quality Evaluation of Compound Ganqi Anti-cough Granules
Objective:To optimize the prescription composition of Compound Ganqi Anti-cough Granules and to establish a quality evaluation method for this preparation.Methods:The contents of ammonium glycyrrhizinate,glycyrrhizin,and astragaloside A were determined by HPLC.The orthogonal experiment[I9(34)]was used to optimize the prescription composition of Compound Ganqi Anti-cough Granules,and its quality was evaluated regarding the quality evaluation items of granules contained in the Chinese Pharmacopoeia.Results:The optimal formulation of granules was 1.0％sodium carboxymethyl cellulose as adhesive,the mixture of starch:dextrin(1:1,w/w)as filler,and 1.2％dry starch as disintegrator.TLC was used to qualitatively identify astragaloside A and glycyrrhizin in granules,and the content of astragaloside A,glycyrrhizin,and ammonium glycyrrhizinate were about 29.21 μg·g-1,2.45 mg·g-1,and 10.72 mg·g-1.Conclusion:The optimized compound Ganqi Anti-cough granules prescription possesses excellent molding and dissolu-tion properties.The quality evaluation method can effectively control the quality of the granules.
万方数据
维普
