Determination of the Genotoxic Impurity 3-Chloropropene in Epichlorhydrin by GC-MS combined with Headspace Injection
Objective:To establish a specific method of the genetic toxicity impurity 3-chloropropene in epichlorhydrin.Methods:The chromatographic column was Agilent DB-624UI,the carrier gas was helium,the flow rate was 1.23 mL·min-1,the inlet temperature was 250 ℃,and the column temperature was programmed to increase.The Vials was incubated at 100 ℃ for 30 min.The electron impact ionization method was used,and the ion source temperature was 230 ℃.The quantitative determination was carried out using the SIM mode.Results:3-chloropropene showed a good linear relationship within the concentration range of 1.044-52.20 ng·mL-1(r=0.999 8).The detection limit and the quantification limit were 0.522 0 and 1.044 ng·mL-1,respectively,and the sample recoveries was 94.13％.Conclusion:The method is good in separation effect,convenient and highly sensitive.It can be used to monitor the quality of epichlorhydrin products.
万方数据
维普
