Effects of Type,Quantity and Blood Concentration of Antiepileptic Drugs Taken During Pregnancy on Pregnancy Outcomes in Pregnant Women with Epilepsy
Objective:To retrospectively analyze the use of antiepileptic drugs during pregnancy and the effect of blood drug concentra-tion on pregnancy outcomes in pregnant women with epilepsy,in order to provide scientific basis for pregnant women with epilepsy to pre-pare for pregnancy and for the safe and effective use of antiepileptic drugs during pregnancy.Methods:The data of antiepileptic drug use and blood drug concentration of women with epilepsy in our hospital during pregnancy preparation and pregnancy from 2017 to 2022 were collected,as well as the pregnancy outcomes.Analyze the effects of the use and concentration of antiepileptic drugs on the control of epi-leptic status of pregnant women and on pregnant women and fetuses.Results:Compared with epilepsy patients with normal term pregnan-cy,the blood concentration of antiepileptic drugs in patients with adverse pregnancy outcomes was generally lower during pregnancy(65.2％vs 9.1％,P=0.002).Compared with new antiepileptic drugs,taking traditional drugs is more likely to cause adverse pregnan-cy outcomes(92.3％vs 19％,P=0.000).The probability of adverse pregnancy outcome of multi-drug combined antiepileptic therapy was also higher than that of single-drug therapy(50％vs 44.4％),but the difference was not statistically significant(P=0.746).Conclusion:Epilepsy control during pregnancy in patients with epilepsy and pregnancy is an important factor that affects pregnancy out-comes.Patients should take anti-epileptic drugs scientifically based on the results of therapeutic drug monitoring.Overworrying about the adverse reactions of anti-epileptic drugs can lead to reduced drug compliance and lower drug concentration in the body,which can increase the risk of adverse pregnancy outcomes.Patients with epilepsy and pregnancy should seek medical advice before pregnancy.Timely and scientific adjustment of the type and quantity of anti-epileptic drugs can reduce the risk of adverse pregnancy.
Epilepsy with pregnancyTherapeutic drug monitoringPregnancy outcome
万方数据
维普
