首页|HPLC法测定金丹附延颗粒中肉桂酸和桂皮醛的含量

HPLC法测定金丹附延颗粒中肉桂酸和桂皮醛的含量

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目的:建立金丹附延颗粒中肉桂酸和桂皮醛的HPLC含量测定方法.方法:采用C18色谱柱,流动相为乙腈和0.1％磷酸溶液,检测器检测波长设置为290 nm,输液泵流速1.0 mL·min-1,色谱柱柱温设置为25 ℃.结果:肉桂酸、桂皮醛分别在0.207 9～10.393 8 μg·mL-1、0.202 5～10.127 0 μg·mL-1 范围内线性关系良好(r=1.000 0),回收率分别为 100.3％、102.6％,回收率RSD分别为1.57％、1.82％.结论:该方法简单、稳定,可用于金丹附延颗粒中肉桂酸和桂皮醛的含量测定.
Determination of Cinnamic Acid and Cinnamic Aldehyde in Jindan Fuyan Granules by HPLC
Objective:To establish a HPLC method for the determination of cinnamic acid and cinnamic aldehyde in Jindan Fuyan granules.Methods:Cinnamic acid and cinnamic aldehyde were separated by C18 column with a mobile phase consisting of acetonitrile-0.1％phosphoric acid solution.The detection wavelength was set at 290 nm with a flow rate of 1.0 mL·min-1 and a chromatographic column temperature of 25 ℃.Results:Cinnamic acid and cinnamic aldehyde were present in the concentration range of 0.207 9-10.3938 μg·mL-1 and 0.202 5-10.127 0 μg·mL-1(r=1.000 0),and the recoveries were 100.3％and 102.6％,RSDs were 1.57％and 1.82％,respectively.Conclusion:The method is simple,stable,and can be used for the determination of cinnamic acid and cinnamic aldehyde in Jindan Fuyan granules.

Jindan Fuyan granuleContent determinationCinnamic acidCinnamic aldehydeHigh Performance Liquid Chromatog-raphy(HPLC)

朱艳艳、刘德鸿、吴倩颖、朱良辉、陈伟康

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江西中医药大学,江西南昌 330004

江西省药品检验检测研究院,国家药品监督管理局中成药质量评价重点实验室,江西省药品医疗器械质量工程研究中心,江西南昌 330029

金丹附延颗粒 含量测定 肉桂酸 桂皮醛 高效液相色谱

江西省药品监督管理局重点项目(2023)

2023JS11

2024

中国药物评价
国家食品药品监督管理局信息中心

中国药物评价

影响因子：1.09
ISSN：2095-3593
年,卷(期)：2024.41(2)
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